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第一部分 奋斗历程1

姚开泰院士介绍3

姚开泰院士自述7

三阳开泰展新篇仁心妙手著人生——记中国科学院院士、著名肿瘤病理生理学家姚开泰9

与时俱进，引领学科潮流——记姚开泰院士的肿瘤研究历程14

第二部分 学术贡献17

一、姚开泰院士的学术成就与学术思想19

二、姚开泰院士的主要学术论文25

The Enforced Expression of c-Myc in Pig Fibroblasts Triggers Mesenchymal-epithelial Transition （MET） via F-actin Reorganization and RhoA/Rock Pathway Inactivation25

MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells42

Embryonic Stem Cells Markers SOX2， OCT4 and Nanog Expression and their Correlations with Epithelial Mesenchymal Transition in Nasopharyngeal Carcinoma63

Aldehyde Dehydrogenase 1， a Functional Marker for Identifying Cancer Stem Cells in Human Nasopharyngeal Carcinoma79

Neoplastic Spindle Cells in Nasopharyngeal Carcinoma Show Features of Epithelial-mesenchymal Transition98

Gene Expression Profile Changes and Possible Molecular Subtypes in Differentiated-type Nonkeratinizing Nasopharyngeal Carcinoma111

Target-specific Cellular Uptake of Taxol-loaded Heparin-PEGfolate Nanoparticles128

GenCLiP： a Software Program for Clustering Gene Lists by Literature Profiling and Constructing Gene Co-occurrence Networks Related to Custom Keywords145

Lentivirus-mediated RNAi Silencing Targeting ABCC2 Increasing the Sensitivity of a Human Nasopharyngeal Carcinoma Cell Line against Cisplatin160

Identification of Label-retaining Cells in Nasopharyngeal Epithelia and Nasopharyngeal Carcinoma Tissues173

An Imageable Metastatic Treatment Model of Nasopharyngeal Carcinoma186

Frequent Hypermethylation of RASSF1A and TSLC1， and High Viral Load of Epstein-Barr Virus DNA in Nasopharyngeal Carcinoma and Matched Tumor-adjacent Tissues197

Proteome Analysis of Anti proliferative Mechanism of 12-O-Tetradecanoylphorbol 13-Acetate on Cultured Nasopharyngeal Carcinoma CNE2 Cells211

Association of PLUNC Gene Polymorphisms with Susceptibility to Nasopharyngeal Carcinoma in a Chinese Population226

Identification of Differentially Expressed Genes in Metastatic and Non-metastatic Nasopharyngeal Carcinoma Cells by Suppression Subtractive Hybridization238

Identification and Characterization of a Novel Nasopharyngeal Carcinoma-associated Peptide： NAP-1252

Construction of Tree Models for Pathogenesis of Nasopharyngeal Carcinoma265

Identification of Differentially Expressed Genes in Nasopharyngeal Carcinoma by Means of the Atlas Human Cancer cDNA Expression Array281

Molecular Cloning of a Novel Tissue-specific Gene from Human Nasopharyngeal Epithelium294

Expression of an Epstein Barr Virus Receptor and Epstein Barr Virus Dependent Transformation of Human Nasopharyngeal Epithelial Cells303

Analysis of DNA Fragments and Polymerase Chain Reaction Products from the Tx Gene by Capillary Electrophoresis with a Laser-induced Fluorescence Detector Using No-gel Sieving Media315

Cytogenetic Study on a New Epithelial Cell Line， HNE-1， Derived from Nasopharyngeal Carcinoma322

Chemical Transformation of Human Embryonic Nasopharyngeal Epithelial Cells in vitro329

Establishment and Characterization of Two Epithelial Tumor Cell Lines （HNE-1 and HONE-1） Latently Infected with Epstein-Barr Virus and Derived from Nasopharyngeal Carcinomas333

用曲细精管微注射法建立绿色荧光蛋白转基因小鼠348

人鼻咽与鼻咽癌cDNA阵谱中DNA修复相关基因表达差异的初步研究355

金属硫蛋白-潜伏膜蛋白融合基因的体外转录调控360

鼻咽及其邻近部位各类型癌组织中EBV DNA的原位检测368

体外培养人胚鼻咽上皮的生物学特性观察 Ⅰ人胚鼻咽上皮体外培养373

从死因回顾调查资料看湖南省鼻咽癌流行病学的一些特点并探索其发病机理378

二亚硝基哌嗪诱发大鼠鼻咽癌的进一步研究385

三、姚开泰院士的重要学术报告393

鼻咽癌研究的回顾与展望393

陈竺等22位中国科学院院士联名向国务院提出建议 以非典型肺炎防治为切入点构筑我国预防医学创新体系399

四、姚开泰院士学术年表402

姚开泰院士担任第一作者或通讯作者SCI收录的英文论文402

姚开泰院士担任第一作者或通讯作者非SCI收录的英文论文407

姚开泰院士担任第一作者或通讯作者的中文论文408

姚开泰院士参加工作的英文论文422

姚开泰院士参加工作的中文论文425

姚开泰院士获得的科研成果429

姚开泰院士获得的荣誉称号431

第三部分 治学之道433

创建“中南大学肿瘤研究所”435

第四部分 大师风范439

姚老师对生物信息学的机敏441

与姚老师相知442

慕名从师443

记姚老师二三事444

与时俱进、诲人不倦的院士——记我的导师姚开泰教授446

我和姚老师的师生情缘447

第五部分 社会影响449

姚开泰院士参加的学术活动、承担的科研项目、担任的学术职务451

各大媒体对姚开泰院士的评价454

姚开泰院士先进事迹457

在姚开泰院士八十寿诞暨从医六十周年庆祝宴会上的讲话459

与时俱进 克癌攻坚——记我国鼻咽癌病理研究专家姚开泰院士461

第六部分 人生风采465