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第一部分 奋斗历程1

曾毅院士成长大事记3

第二部分 学术贡献7

一、曾毅院士主要学术成就和学术思想9

肿瘤病毒和艾滋病病毒的研究及其防治领域的开拓者9

二、曾毅院士代表性学术论文11

Establishment of an Epithelioid Cell Line and a Fusiform Cell Line from a Patient withNasopharyngeal Carcinoma①11

Application of an Immunoenzymatic Method and an Immunoautoradiograhic Methodfor a Mass Survey of Nasopharyngeal Carcinoma20

Development of an Anticomplement Immunoenzyme Test for Detection of EB VirusNuclear Antigen（EBNA） and Antibody to EBNA25

Inhibitory Effect of Retinoids on Epstein-Barr Virus Induction in Raji Cells28

Serological Mass Survey for Early Detection of Nasopharyngeal Carcinoma in Wuzhou City，China31

Follow-up Studies on Epstein-Barr Virus IgA/VCA Antibody-Positive Persons inZangwu County，China35

Epstein-Barr Virus Early Antigen Induction in Raji Cells by Chinese Medicinal Herbs39

Epstein-Barr Virus-Activating Principle in the Ether Extracts of Soils Collected fromunder Plants which Contain Active Diterpene Esters43

Comparative Evaluation of Various Techniques to Detect EBV DNA in ExfoliatedNasopharyngeal Cells47

Detection of Epstein-Barr Virus IgA/EA Antibody for Diagnosis of NasopharyngealCarcinoma by immunoautoradiography53

Presence of EBV-DNA Sequences in Nasopharyngeal Cells of Individuals withoutIgA-VCA Antibodies57

Early Nasopharyngeal Carcinoma Among IgA/VCA Antibody Positive IndividualsDetected by Anticomplement Immunoenzymatic Method62

HTLV Antibody in China65

Epstein-Barr Virus Activation in Raji Cells with Ether Extracts of Soil from DifferentAreas in China66

Epstein-Barr Virus Activation by Human Semen Principle： Synergistic Effect of Culture Fluids of Bacteria Isolated from Patients with Carcinoma of Uterine Cervix70

Prospective Studies on Nasopharyngeal Carcinoma in Epstein-Barr Virus IgA/VCA Antibody-Positive Persons in Wuzhou City，China73

Seroepidemiological studies on Nasopharyngeal Carcinoma in China77

Nasopharyngeal Carcinoma：Early Detection and IgA-Related pre-NPC Condition，Achievements and Prospectives86

Nasopharyngeal Mucosal Changes in EB Virus VCA-IgA Antibody Positive Persons91

ELISA for the Detection of Nasopharyngeal Carcinoma Using IgA Antibodies to EBV Early Antigen96

Detection of IgG and IgA Antibodies to Epstein-Barr Virus Membrane Antigen in Sera from Patients with Nasopharyngeal Carcinoma and from Normal Individuals102

Epstein-Barr Virus Activation in Raji Cells by Extracts of Preserved Food from High Risk Areas for Nasopharyngeal Carcinoma105

Wikstroemia Indica Promotes Development of Nasopharyngeal Carcinoma in Rats Initiated by Dinitrosopiperazine108

Linkage of a Nasopharyngeal Carcinoma Susceptibility Locus to the HLA Region111

Diagnosis of Nasopharyngeal Carcinoma by Means of Recombinant Epstein-Barr Virus Proteins114

Salivary and Serum IgA Antibodies to the Epstein-Barr Virus Glycoprotein gp340：Incidence and Potential for Virus Neutralization120

Detection of Anti-Epstein-Barr-Virus Transactivator（Zebra） Antibodies in Sera from Patients with Nasopharyngeal Carcinoma128

A Research for the Relationship between Human Papillomavirus and Human Uterine Cervical Carcinoma132

A Research for the Relationship between Human Papillomavirus and Human Uterine Cervical Carcinoma140

Suppression of Human Nasopharyngeal Carcinoma Cell Growth in Nude Mice by the Wild-Type p53 Gene152

A 10-Year Prospective Study on Nasopharyngeal Carcinoma in Wuzhou City and Zangwu County， Guangxi，China156

Urinary Excretion of Nitrosamino Acids and Nitrate by Inhabitants of High and Low Risk Areas for Nasopharyngeal Carcinoma in Southern China161

Environmental and Dietary Risk Factors for Nasopharyngeal Carcinoma：A Case- Control Study in Zangwu County，Guangxi，China168

Establishment of a Human Malignant T Lymphoma Cell Line Carrying a Retrovirus- like Particle with RT Activity178

Screening of Epstein-Barr Virus Early Antigen Expression Inducers from Chinese Medicinal Herbs and Plants186

Serological Survey of Nasopharyngeal Carcinoma in 21 Cities of South China191

Detection of Epstein-Barr Virus DNA in well and Poorly Differentiated Nasopharyngeal Carcinoma Cell Lines195

Epstein-Barr Virus Strain Variation in Nasopharyngeal Carcinoma from the Endemic and Non-Endemic Regions of China201

Synergistic Effect of Epstein-Barr Virus and Tumor Promoters on Induction of Lymphoma and Carcinoma in Nude Mice214

Study of Immortalization and Malignant Transformation of Human Embryonic Esophageal Epithelial Cells Induced by HPV18 E6E7221

Detection of Human Papillomavirus in Esophageal Carcinoma228

Progressive Transformation of Immortalized Esophageal Epitbelial Cells234

The Multistage Process of Carcinogenesis in Human Esophageal Epithelial Cells Induced by Human Papillomavirus241

Malignant Transformation of Human Embryonic Liver Cells Induced by Hepatitis B Virus and Aflatoxin B1251

Construction and Characterization of Chimeric BHIV（BIV/HIV-1）Viruses Carrying the Bovine Immunodeficiency Virus Gag Gene257

Induction of Cytotoxic T Lymphocyte Respones in vivo after Immunotherapy with Dendritic Cells in Patients with Nasopharyngeal Carcinoma265

In vitro Anti-Tumor Immune Response Induced by Dendritic Cells Transfected withEBV-LMP2 Recombinant Adenovirus272

Immunogenicity of the Recombinant Adenovirus Type 5 Vector with Type 35 Fiber Containing HIV-1 Gag Gene280

Haplotype-dependent HLA Susceptibility to Nasopharyngeal Carcinoma in a Southern Chinese Population286

The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition Groove297

Phylogenetic and Temporal Dynamics of Human Immunodeficiency Virus Type 1 CRF01 AE in China310

Haplotype-dependent HLA Susceptibility to Nasopharyngeal Carcinoma in a Southern Chinese Population318

三、曾毅院士学术年表329

曾毅院士中文论文目录329

曾毅院士英文论文目录356

曾毅院士主要获奖奖项370

第三部分 大师风范373

巍巍科山不老松375

科学青春永驻378

鸿儒硕学 高瞻远瞩379

毅者人生381

曾毅：只为挽救更多生命384

快乐老人的预防哲学388

A Controversial Bid to Thwart the “Cantonese Cancer”389

第四部分 社会影响393

普查人类癌症的第一个例证395

这是首次证明EB病毒可以在体内诱发实验性癌症396

对鼻咽癌细胞中EB病毒标记的阐述是举世无双的398

当代医学上的一个里程碑400

曾毅教授的贡献值得国际、国内科学界的承认和赞扬402

中国科学院贺信404

第五部分 人生风采405

科研工作407

国际交流409

重要时刻415

珍贵合影417

幸福生活418