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PART Ⅰ－GENERAL PHYSICOCHEMICAL AND PHYSIOLOGIC CONSIDERATIONS OF HYPOTHERMIA1

Some Considerations of Physicochemical Factors in Hypothermia＆D．E．S．Brown1

Effects of Hypothermia on General Metabolism＆S．M．Horvath and G．B．Spurr8

The Effect of Low Temperatures upon Intracellular Potassium in Isolated Tissues＆I．M．Taylor26

Potassium Exchange in Perfused Mammalian Skeletal Muscle＆E．M．Renkin32

Electrolyte Transfer during Hypothermia＆Frank Gollan37

Myocardial Balance of Potassium＆Henry Swan42

Effects of Low Body Temperature on Tissue Oxygen Utilization＆E．F．Adolph44

Oxygen Consumption of Mammalian Tissue at Reduced Temperatures＆F．A．Fuhrman50

Respiratory Physiologic Studies During Hypothermia＆J．W．Severinghaus and M．Stupfei52

The Gas Transport System in Hypothermia＆F．F．Kao58

Hypothermia in the Unanesthetized Poikilothermic Dog＆A．D．Keller61

Discussion：＆A．C．Burton，J．W．Severinghaus，and J．Cahn78

Physiology of Hibernation in Mammals＆C．P．Lyman and P．O．Chat field80

Discussion：＆A．C．Burton，A．D．Keller；E．Calkins，G．E．Burch，J．D．McMurrey，H．Swan，C．McC．Brooks，and R．K．Andjus122

Resuscitation and Recovery of Hypothermic，Supercooled，and Frozen Mammals＆R．K．Andjus，J．E．Lovelock，and A．U．Smith125

Discussion：＆F．J．Lewis，J．W．Severinghaus，W．Parkins，A．L．Hopkins，J．Fine，R．W．Brauer，F．D．Moore，R．D．Dripps，and J．Henley143

PART Ⅱ－THE EFFECTS OF HYPOTHERMIA ON SPECIFIC SYSTEMS146

Cardiovascular Functions in Deep Hypothermia＆H．E D＇Amato146

Discussion：＆I．K．R．McMillan and E．Friedman155

The Circulation During Rewarming＆Henry Swan161

Discussion：＆R．O．Heimbecker and J．Fine161

Coronary Blood Flow During Hypothermia＆R．M．Berne165

The Effect of Hypothermia on Pituitary ACTH Release and on Adrenal Cortical and Medullary Secretion in the Dog＆D．M．Hume，R．H．Egdahl，and D．H．Nelson170

Discussion：＆A D．Keller，M．E．De Bakey，J．R．Pappenheimer，and F．D．Moore173

The Effect of Hypothermia on the Peripheral Serum Levels of Free 17-Hydroxycorticoids in the Dog，and in Man＆W．F．Bernhard175

Discussion：＆J．Cahn and H．Swan178

Some Problems of Hematology in Hypothermia：An Introduction＆William H．Crosby，Jr183

The Effect of Hypothermia on Platelets and White Cells in Dogs＆T．J．Villalobos，E．Adelson，and P．A．Riley186

Discussion：＆C．M．Couves，D．Warren，J．E．Rhoads，J．A．Helmsworth，and J．Adams-Ray194

Renal Functional Response to Hypothermia and Ischemia in Man and Dog＆J．H．Moyer，G．C．Morris，and M．E．De Bakey199

Effect of Hypothermia on the Kidney＆R．K．Andjus214

Discussion：＆P．A．Riley218

Hypothermia and Temporary Occlusion of the Hepatic Circulation＆N．E．Shumway and F．J．Lewis221

Effect of Hypothermia on Metabolism and Drug Detoxification in the Isolated Perfused Rabbit Liver＆I．Gray，R．R．Rueckert，and R．R．Rink226

The Effect of Hypothermia on the Isolated Perfused Rat Liver＆R．W．Brauer235

Effects of Cold on the Nervous System＆I．D．McQueen243

Effects of Changes in Arterial pCO2 on Cerebral Blood Flow and Metabolism during Hypothermia＆I．Kleinerman251

Hypothermia and the Central Nervous System＆H．L．Rosomoff253

Hypothermia and the Nervous System＆C．McC．Brooks260

Experimental and Clinical Observations on the Use of Hypothermia to Prevent Ischemic Damage to the Central Nervous System＆R．G．Pontius and M．E．De Bakey264

Discussion：＆W．H．Lougheed270

Possibilities and Limitations of Differential Brain Cooling in Dogs＆J．M．Jensen，W．M．Parkins，and H．M．Vars271

Discussion：＆W．M．Parkins，J．Cahn，and J．D．McMurrey274

REVIEW AND APPRAISAL OF PARTS Ⅰ AND Ⅱ＆J．W．Severinghaus279

REVIEW AND APPRAISAL OF PARTS Ⅰ AND Ⅱ＆S．M．Horvath284

PART Ⅲ－MYOCARDIAL IRRITABILITY AND HYPOTHERMIA287

Hypothermia and the Physiology of Cardiac Excitability＆C．McC．Brooks287

Temperature Effects on Cardiac Transmembrane Potentials＆B．F．Hoflman302

Discussion：＆G．E．Burch，J．W．Severinghaus．and D．Durrer324

Myocardial Irritability in Experimental Immersion Hypothermia＆A．H．Hegnauer and B．G．Covino327

Discussion：＆F．J．Lewis，B．F．Hoffman，F．Gollan，A．Riberi，and J．Cahn340

REVIEW AND APPRAISAL OF PART Ⅲ－C．McC．Brooks and B．F．Hoffman355

PART Ⅳ－CLINICAL APPLICATION OF INDUCED HYPOTHERMIA363

Hypothermia in Neurosurgery＆E．H．Botterell and W．M．Lougheed363

Discussion：＆G．H．Clowes，Jr．，W．M．Lougheed，and E．H．Botterell368

Effect of Hypothermia on Tolerance to Hemorrhagic Shock＆E．W．Friedman，D．Davidoff，and Jacob Fine369

Discussion：＆E．Frank378

Experimental Observations on the Influence of Hypothermia and Autonomic Blocking Agents on Hemorrhagic Shock＆R．C．Overton and M．E．De Bakey381

Hypothermia and Experimental Myocardial Infarction＆Charles Huggim392

Treatment of the Seriously Ill，Febrile Patient with Surface Cooling＆F．J．Lewis，D．M．Ring，and J．F．Alden394

Discussion：＆W．J．Kolff，E．Calkins，H．Swan，F．J．Lewis，J．Henley，and C．W．Hughes399

The Use of Hypothermia in Cardiac Surgery＆Henry Swan402

Discussion：＆F．J．Lewis，J．H．Kay，I．K．R．McMillan，W．P．Longmire，Jr．，J．Cahn，C．W．Hughes，and H．Swan409

REVIEW AND APPRAISAL OF PART Ⅳ＆R．D．Dripps413

PART Ⅴ－TECHNIQUES OF INDUCING HYPOTHERMIA415

Problems in Methods of Inducing Hypothermia by Use of External Cooling＆W．H．Muller，Jr．and J．F．Dammann415

Problems in Methods of Inducing Hypothermia by Use of Drugs and Internal Cooling＆J．F．Dammann and W．H．Muller，Jr422

Discussion：＆J．Adams-Ray，A．Riberi，R．O．Heimbecker，F．Gollan，R．W．Brauer，and L．I．Goldberg430

REVIEW AND APPRAISAL OF PART Ⅴ＆R．D．Dripps439

Attendance441

Index of Authors and Discussants447